Neutrophil Sling: a New Cell-Autonomous Adhesive Structure Enabling Rolling at High Shear Stress

Cell-Autonomous Regulation of Neutrophil

Structure Evolution of a Polymer Solution at High Shear Rates

We utilized large angle light scattering to study the structure of a sheared semidilute polymer solution. Below a critical shear rate γ̆c we observe an enhancement of concentration fluctuations in accordance with previous experimental and theoretical work. Above γ̆c we find dramatic changes in the transient and steady state scattering behavior which indicate a shear-induced phase separation. A ne...

Neutrophil mechanotransduction: A GEF to sense fluid shear stress

Forces deriving from blood flow shear modulate vascular adherence and transendothelial migration of leukocytes into inflamed tissues, but the mechanisms by which shear is sensed are unclear. In this issue, Fine et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603109) identify the guanosine nucleotide exchange factor GEF-H1 as critical for shear stress-induced transendothelial neutro...

Shear bond strength of a new fluoride-releasing orthodontic adhesive.

This study evaluated the shear bond strength of stainless steel brackets bonded to enamel with a new fluoride-releasing orthodontic adhesive system. A total of 140 extracted human bicuspids were randomly divided into four groups. Group I (Transbond XT) was a control group in which enamel was etched with phosphoric acid. For the remaining groups, enamel was conditioned with a self-etching primer...

Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress.

Verotoxin-1 (VT-1)-producing Escherichia coli is the causative agent of postdiarrheal hemolytic uremic syndrome (D+HUS) of children, which leads to renal and other organ microvascular thrombosis. Why thrombi form only on arterioles and capillaries is not known. This study investigated whether VT-1 directly affected endothelial antithrombogenic properties promoting platelet deposition and thromb...